by Linda Gladhill

The Journal of Investigative Dermatology (2003) Nº 121, pages 20–27 reports that the early manifestation of acne lesions is hypercornification of the follicle walls. The cells that line the walls of the sebum ducts when affected by acne have thicker membranes and are kept together by many layers of keratinized cells compacted together.

The pilosebaceous ductal hypercornification can be seen histologically as microcomedones and clinically as blackheads, whiteheads, and other forms of comedones, such as macrocomedones.

This hypercornification gives rise to the ‘‘horny’’ plug, which is formed within the follicular duct/lumen. When these horny plugs are sloughted off as such, as if they were hardened or solidified lava in a volcano-like eruption they can not but further damage the follicle ducts.

This is dissimilar to the nature of the cells found lining the walls of normal follicles, which lose their integrity and are sloughed of as single or smaller groups of cells.

These lesions inflicted to the cells of the walls of the ducts through which sebum is supposed to flow from the sebaseous glands inside the follicle to the surface of the skin is characteristic of the first stage of what latter becomes an acne breakout.

There is ample evidence of the involvement of inflammatory events in the very earliest stages of acne lesion development. Quantitative assessment has identi¢ed significant inflammatory factors around clinically normal pilosebaceous follicles from uninvolved skin from acne patients prior to hyperproliferation of the follicular epithelium.

Around uninvolved follicles there were large numbers of CD4þ T cells over and above the constitutive level of surveillance T cells in normal skin, accompanied by a large macrophage presence, which was equivalent to that observed in clinically apparent early (o6h) inflamed lesions.

In addition, there was a notable absence of neutrophils and a low number of CD8þ T cells within the cellular infiltrate, similar to that in normal skin. The decrease in dermal and especially epidermal Langerhans cell numbers in the skin around these follicles suggests migration of these cells to the skin draining lymph nodes.Within the CD4þ T cell population, the majority were memory/e¡ectors, with a similar proportion exhibiting a skin homing phenotype. This would suggest the start of a speci¢c in£ammatory response from the adaptive immune system. Despite the increase in cellular in¢ltrate, however, the absence of an increase in the cellular expression of HLA-DR within the in¢ltrate would indicate a lack of activation of these cells.

The results from this study suggest that inflammatory events occur prior to and act as possible causal factors in the hyperproliferative changes observed in acne lesions, as opposed to secondary consequential events. The demonstration that an increase in IL-1 activity occurs prior to that of hyperproliferation around uninvolved follicles also coincides with the ‘‘keratinocyte activation cycle’’ proposed by Freedberget al (2001), in which keratinocytes can be activated via the release of IL-1, with activation markers K6 and K16 being expressed as a subsequent event. Thus, this would give weight to
the argument that acne vulgaris should be classi¢ed as an inflammatory skin disease as opposed to a keratinocyte/hyperproliferative disorder. This study also provides good evidence to support the treatment of uninvolved skin in acne patients and not just the visible lesions alone and may validate the topical use of anti-inflammatory based therapies for this skin disorder.

The secret of BIOSKINFORTE lies on its 100% natural formula that combines a potent natural serum that functions as an innate immune system support with the most powerful anti-inflammatory, antimicrobial, anti-irritant and sebum regulation botanicals.

Linoleic acid is a natural compound of sebum. Sebaceous glands, found within hair follicles, release sebum to provide lubrication of follicles and surrounding skin. The body requires these essential fatty acids, linoleic and alpha-linoleic acids, more known as Omega-3 and 6.

Studies have discovered links that propose that Trans fats may break down the body's own supply of linoleic and alpha-linoleic acids. This is why acne breakouts are more likely to appear in people that have a deficiency in Omega-3 and Omega-6 oils.

Sebum output begins to be produced with oleic acid that can cause irritation to the skin which is why acne can appear. It has been proposed that oleic acid sebum is drier, stiffer and more prone to cause blackheads, whiteheads and to shape follicular plugs which lead to blemish infections.

Omega-3 is known to reduce inflammation and Omega-6 promotes inflammation. A deficiency in these oils contributes to the development of disease while a proper balance aids to maintain and promote well being.

A Biological Source of Linoleic Fats

Inca Inchi oil is a beneficial compound found in biological acne treatments. The oil is the best source of linoleic and alpha-linoleic acids among other necessary compounds. Medical research has proven that linoleic and alpha-linoleic acids are effective in topical creams when treating acne blemishes.

The oil conserves healthy cutis and generally helps the entire organism to remain in balance. Extensive studies have also proved that these fatty acids allow the protection of the cutaneous lipidic balance, avoiding keratinization problems, diminishing inflammation and irritation associated with acne lesions.

Acne treatments that contain Inca Inchi Oil will have a rich supply of Vitamin A which is a known anti-microbial. This vitamin is required for the normal function of the immune system and has been used by professionals to prevent conditions of the skin. It also contains important antioxidants that diminish skin inflammation; chemicals that prevent the oxidation of other chemicals. Oxidation can produce extremely reactive free radicals react with and damage other and more important molecules.

Trans fats are rapidly replacing linoleic and alpha linoleic acids in foods, which can cause a deficiency in the body, triggering breakouts. Inca Inchi Oil is a beneficial compound due to its high nutritional value. Skin care treatments that contain this very beneficial constituent will promote overall health and well-being, diminishing problem skin conditions for good.

BIOSKINFORTE- a natural acne solution made with powerful natural ingredients.